![]() ![]() We have a bunch of hcw’s getting 1st shot. Researchers could randomize the healthcare providers receiving the vaccines and compare the efficacy of different dosing regimens.Īnd what I have read in terms of the risks of this approach are data free arguments about how delaying or even missing the second shot is not that big a deal. ![]() could essentially run real-world tests of the dosing regimens. Peter Bach, director of Memorial Sloan Kettering’s center for health policy and outcomes, also suggested that the U.K. “Pfizer believes it is critical health authorities conduct surveillance efforts on any alternative schedules implemented and to ensure each recipient is afforded the maximum possible protection, which means immunization with two doses of the vaccine,” the New York pharma added. “There are no data to demonstrate that protection after the first dose is sustained after 21 days,” Pfizer stressed in a statement. While Britain’s top medical officials touted the arrangement as “much more preferable in public health terms,” the decision immediately drew criticism because prolonged dosing intervals weren't tested in the clinical trials supporting the vaccines’ emergency authorizations.īNT162b2, for example, was tested in two doses three weeks apart, and its U.S. “It is a classic public health approach centered on doing as much good for as many people in the shortest possible timeframe, within the available vaccine supplies, against a background of immediate disease activity and still high population sero-susceptibility,” the country’s chief medical officers wrote in an open letter to U.K. RELATED: Moderna scores FDA authorization for its COVID-19 vaccine, adding key 2nd shot as nationwide campaign ramps up health authorities have allowed the gap between the two required doses-the initial plus a follow-up booster-to extend from four or three weeks to as much as 12 weeks for the AstraZeneca and Pfizer-BioNTech shots. Aiming to immunize more people with a first dose quickly, U.K. government’s approval of a more spaced-out dosing schedule for AstraZeneca’s AZD1222 and Pfizer and BioNTech’s BNT162b2. Slaoui made that comment in response to a question about the U.K. has ordered a total of 200 million doses of the Moderna vaccine, with about 20 million earmarked for 2020. Slaoui argued that reducing the dosing strength by half could cover twice as many people with the current supply. Moderna declined to comment on potential ongoing regulatory discussions.Ĭurrently, mRNA-1273 is authorized by the FDA in two injections at the 100 μg dose four weeks apart. ![]()
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